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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC6
All Species:
41.21
Human Site:
Y489
Identified Species:
69.74
UniProt:
Q99741
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99741
NP_001245.1
560
62720
Y489
L
G
K
L
Y
E
A
Y
S
K
V
C
R
K
Q
Chimpanzee
Pan troglodytes
XP_001170406
560
62717
Y489
L
G
K
L
Y
E
A
Y
S
K
V
C
R
K
Q
Rhesus Macaque
Macaca mulatta
XP_001096756
559
62520
Y488
L
G
K
L
Y
E
A
Y
S
K
V
C
R
K
Q
Dog
Lupus familis
XP_537648
559
62507
Y488
L
G
K
L
Y
E
A
Y
S
N
V
C
R
K
Q
Cat
Felis silvestris
Mouse
Mus musculus
O89033
562
62595
Y491
L
G
K
L
Y
E
A
Y
S
S
I
C
R
K
Q
Rat
Rattus norvegicus
NP_001101768
561
62295
Y490
L
G
K
L
Y
E
A
Y
S
S
V
C
R
K
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519126
361
39672
Q305
A
R
A
N
C
R
P
Q
L
L
N
F
P
P
Y
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001081844
554
60731
Y484
L
G
K
V
H
E
A
Y
S
K
V
C
R
K
Q
Zebra Danio
Brachydanio rerio
NP_001120805
561
61262
Y490
L
G
K
L
C
E
V
Y
S
K
L
C
K
Q
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648247
662
75116
Y588
M
G
R
L
H
E
V
Y
R
R
V
C
A
K
R
Honey Bee
Apis mellifera
XP_625142
549
62089
Y477
V
G
R
L
H
E
V
Y
K
K
V
C
K
K
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999666
582
64455
Y501
L
G
K
V
H
D
T
Y
C
K
I
C
A
S
R
Poplar Tree
Populus trichocarpa
XP_002299817
498
55546
P442
C
K
S
T
I
I
P
P
V
G
I
L
E
F
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P09119
513
58018
E457
L
A
P
L
Q
R
N
E
F
L
E
I
C
T
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96
89.1
N.A.
79.5
80
N.A.
45.3
N.A.
63.7
49
N.A.
33.9
36
N.A.
40
Protein Similarity:
100
100
97.5
93.5
N.A.
87.3
88.9
N.A.
52.8
N.A.
77.5
67.3
N.A.
52.1
57.3
N.A.
58.5
P-Site Identity:
100
100
100
93.3
N.A.
86.6
93.3
N.A.
0
N.A.
86.6
60
N.A.
46.6
53.3
N.A.
40
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
0
N.A.
100
86.6
N.A.
80
86.6
N.A.
73.3
Percent
Protein Identity:
25.8
N.A.
N.A.
N.A.
20.1
N.A.
Protein Similarity:
46.4
N.A.
N.A.
N.A.
41.2
N.A.
P-Site Identity:
0
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
8
0
0
0
50
0
0
0
0
0
15
0
0
% A
% Cys:
8
0
0
0
15
0
0
0
8
0
0
79
8
0
0
% C
% Asp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
72
0
8
0
0
8
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
8
0
8
0
% F
% Gly:
0
79
0
0
0
0
0
0
0
8
0
0
0
0
0
% G
% His:
0
0
0
0
29
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
8
0
0
0
0
22
8
0
0
8
% I
% Lys:
0
8
65
0
0
0
0
0
8
50
0
0
15
65
0
% K
% Leu:
72
0
0
72
0
0
0
0
8
15
8
8
0
0
8
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
8
0
0
8
8
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
15
8
0
0
0
0
8
8
0
% P
% Gln:
0
0
0
0
8
0
0
8
0
0
0
0
0
8
50
% Q
% Arg:
0
8
15
0
0
15
0
0
8
8
0
0
50
0
29
% R
% Ser:
0
0
8
0
0
0
0
0
58
15
0
0
0
8
0
% S
% Thr:
0
0
0
8
0
0
8
0
0
0
0
0
0
8
0
% T
% Val:
8
0
0
15
0
0
22
0
8
0
58
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
43
0
0
79
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _